LAPAROSCOPIC SLEEVE GASTRECTOMY AND GASTRIC PLICATION: INFLUENCE ON THE MAIN INDICATORS OF HORMONAL HOMEOSTASIS IN METABOLIC SYNDROME

Improvements in living standards have led to an increase the annual global incidence of obesity 13% among adults 2021.
 Laparoscopic gastroplication is safe perform, essentially organ-preserving and relatively inexpensive from economic point view.
 Among advantages should be included its simplicity performance, which makes a wider circle use. It also noted that during there no crossing organ cavity (stomach), such complications as failure suture line, bleeding line impossible. However, it remains relevant determine effect this type intervention on level orexogenic anorexigenic hormones postoperative period.
 Aim research: evaluate influence sleeve-gastrectomy gastric plication main indicators hormonal homeostasis metabolic syndrome.
 The Goal sleeve gastrectomy Materials methods. work based materials clinical examination surgical treatment 12 patients with syndrome, 4 men 8 women aged 45±3.75 years body mass index >40 kg/m2. Depending chosen intervention, all study were divided into two groups: laparoscopic - 5 patients, 7 patients.
 Results. A decrease ghrelin concentration was established weeks after sleeve-1 surgery by 35.06% (p=0.0595), while 3 months indicator decreased 58.57% (p=0.0065), 6 60.31% (p=0.0057 ). Gastric demonstrated (1 month – 22.17% (p=0.1290), 32.82% (p=0.0245), however, did not cause significant corresponding time periods. use sleeve-2 methods showed leptin, evidence degree resistance. Thus, terms 1, months, serum 38.47% (p=0.0342), 54.67% (p=0.0056), 56.95% (p=0.0069), respectively. And word-2 24.67% (p =0.1230), 35.68% (p=0.0193), 48.29% (p=0.0028), respectively.
 On other hand, used bariatric interventions caused adiponectin. Its increased 7.14% (p=0.9124) 1 month, 30.63% (p=0.5741) 36.64% (p=0.4093) six surgery. After plication, 7.71% (p=0.8731), 16.71% (p=0.6198) 30.89% (p=0.4304) registered respective observation periods.
 Conclusions. Significant changes levels adipokines surgery, adiponectin indicate high potential reducing manifestations syndrome risk developing 2 diabetes. ghrelin, interacts these feedback type, trigger for regulation homeostasis, can achieved